Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly aft...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 77; no. 7; pp. 875 - 878
Main Authors DEVKOTA, Bhuminad, TAKAHASHI, Masahiro, SATO, Saori, SASAKI, Kouya, UEKI, Atsushi, OSAWA, Takeshi, YAMAGISHI, Norio
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2015
The Japanese Society of Veterinary Science
Subjects
Acid Phosphatase - blood
Acid Phosphatase - physiology
Animals
Biomarkers - blood
Bone Resorption - blood
Bone Resorption - physiopathology
Bone Resorption - veterinary
Calcium - blood
Cattle - blood
Cattle - physiology
Collagen Type I - blood
Collagen Type I - physiology
dairy cow
Estradiol - blood
Estradiol - physiology
Female
Hydroxyproline - blood
Internal Medicine
Isoenzymes - blood
Isoenzymes - physiology
osteoclast-mediated bone resorption
osteocytic remodeling
Parathyroid Hormone - blood
parturition
Parturition - blood
Parturition - physiology
Peptides - blood
Peptides - physiology
Tartrate-Resistant Acid Phosphatase
tartrate-resistant acid phosphatase isoform 5b (TRAP5b)
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Summary:Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.15-0018