Friulimicins: Novel Lipopeptide Antibiotics with Peptidoglycan Synthesis Inhibiting Activity from Actinoplanes friuliensis sp. nov I. Taxonomic Studies of the Producing Microorganism and Fermentation

• Published in: Journal of antibiotics Vol. 53; no. 8; pp. 807 - 815
• Main Authors: ARETZ, W., MEIWES, J., SEIBERT, G., VOBIS, G., WINK, J.
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.08.2000; Japan Antibiotics Research Association
• Subjects: Actinomycetales - classification; Actinomycetales - metabolism; Actinomycetales - physiology; Actinoplanes friuliensis; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Drug Evaluation, Preclinical - methods; Fatty Acids - metabolism; Fermentation; friulimicins; Fundamental and applied biological sciences. Psychology; lipopeptide antibiotics; Microbial Sensitivity Tests; Microbiology; Peptidoglycan - biosynthesis; Peptidoglycan - drug effects; peptidoglycans; Protein Synthesis Inhibitors - metabolism; Protein Synthesis Inhibitors - pharmacology; Peptidoglycan; Antibiotic; Peptides; Microorganism culture; Bacteria; Lipids; Actinomycetes; Antibacterial agent; Fermentation; Fatty acids; In vitro; Biological activity
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.53.807

A strain that produces new lipopeptide antibiotics is a new species of the genus Actinoplanes for which we propose the name Actinoplanes friuliensis (type strain: HAG 010964). The strain is an actinoplanete actinomycete having cell wall II composition and forming sporangia. Comparisons with Actinoplanes spp. which have similarities with our isolate, including fatty acid analysis, showed that the isolate belongs to a new species. Taxonomic studies and fermentation are presented.