Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

• Published in: BMC medical genetics Vol. 19; no. 1; pp. 38 - 12
• Main Authors: Ding, Weiyue, Xu, Li, Zhang, Lejun, Han, Zhijie, Jiang, Qinghua, Wang, Zhe, Jin, Shuilin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.03.2018; BioMed Central; BMC
• Subjects: Alleles; Asian People - genetics; Cellular signal transduction; Databases, Factual; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; Gene expression; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Humans; Meta-analysis; Polymorphism; Polymorphism, Single Nucleotide; Publication Bias; Risk factors; rs7903146; T2DM; Transcription Factor 7-Like 2 Protein - genetics; Transcription factors; Type 2 diabetes; White People - genetics; T2DM; rs7903146; Meta-analysis; Polymorphism

Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we...