Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus

• Published in: BMC medical genetics Vol. 19; no. 1; pp. 38 - 12
• Main Authors: Ding, Weiyue, Xu, Li, Zhang, Lejun, Han, Zhijie, Jiang, Qinghua, Wang, Zhe, Jin, Shuilin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.03.2018; BioMed Central; BMC
• Subjects: Alleles; Asian People - genetics; Cellular signal transduction; Databases, Factual; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; Gene expression; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Humans; Meta-analysis; Polymorphism; Polymorphism, Single Nucleotide; Publication Bias; Risk factors; rs7903146; T2DM; Transcription Factor 7-Like 2 Protein - genetics; Transcription factors; Type 2 diabetes; White People - genetics; T2DM; rs7903146; Meta-analysis; Polymorphism
• ISSN: 1471-2350; 1471-2350
• DOI: 10.1186/s12881-018-0553-5

Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result. The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta. The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, p < 0.0001). The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.