New Cytotoxic Agents, BE-52440A and B, Produced by a Streptomycete

• Published in: Journal of antibiotics Vol. 53; no. 7; pp. 687 - 693
• Main Authors: TSUKAMOTO, MASAO, NAKAJIMA, SHIGERU, MUROOKA, KUMIKO, NAITO, MINORU, SUZUKI, HAJIME, HIRAYAMA, MIOKO, HIRANO, KAORI, KOJIRI, KATSUHISA, SUDA, HIROYUKI
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.07.2000; Japan Antibiotics Research Assoc; Japan Antibiotics Research Association
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Applied microbiology; BE-52440A; BE-52440A agent; BE-53440B; BE-53440B agent; Biological and medical sciences; Biotechnology & Applied Microbiology; Chemotherapic agents; Classification; Drug Screening Assays, Antitumor; Fermentation; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Immunology; Inhibitory Concentration 50; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Microbiology; Molecular Structure; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyrans - chemistry; Pyrans - isolation & purification; Pyrans - pharmacology; Science & Technology; Spectrometry, Mass, Fast Atom Bombardment; Streptomyces; Streptomyces - classification; Streptomyces - metabolism; Tumor Cells, Cultured; NANAOMYCINS; STRAIN; Antineoplastic agent; Streptomycetaceae; Streptomyces; Cytotoxicity; Fermentation; In vitro; Biological activity; Actinomycetales; Established cell line; Microorganism culture; Bacteria; Actinomycetes; Tumor cell; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.53.687

New cytotoxic substances, designated BE-52440A and B, were isolated from the mycelium of Streptomyces sp. A52440. The active principles were extracted from the mycelium by methanol and purified by silica gel column chromatography. BE-52440A and B exhibited cytotoxic activity against murine and human tumor cell lines.