Stage migration due to introduction of the sentinel node procedure: a population-based study

• Published in: Breast cancer research and treatment Vol. 113; no. 1; pp. 173 - 179
• Main Authors: Maaskant, A. J. G, van de Poll-Franse, L. V, Voogd, A. C, Coebergh, J. W. W, Tutein Nolthenius-Puylaert, M. C. B. J. E, Nieuwenhuijzen, G. A. P
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.01.2009; Springer US; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Adult; Aged; Biological and medical sciences; Biopsy; Breast cancer; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cancer research; Cancer therapies; Epidemiology; False Negative Reactions; Female; Gynecology. Andrology. Obstetrics; Humans; Lymphatic system; Mammary gland diseases; Mastectomy, Segmental; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Netherlands; Oncology; Registries; Sentinel Lymph Node Biopsy - methods; Sentinel Lymph Node Biopsy - trends; Tumors; Netherlands; Micrometastasis; Breast carcinoma; Stage migration; Sentinel node biopsy; Breast disease; Node; Breast cancer; Malignant tumor; Sentinel node biopsy . Stage migration; Mammary gland diseases; Anatomic pathology; Clinical stage; Biopsy; Procedure; Cell migration; Public health; Cancer
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1007/s10549-008-9913-8

Background Introduction of sentinel node biopsy (SNB) as an axillary staging procedure in breast cancer patients could have led to upstaging as well as downstaging of their disease. Intensified pathological processing could have led to upstaging due to presence of micrometastases, whereas the described false negative rate of 5% could be a cause of downstaging. We investigated whether or not the introduction of the sentinel node procedure has changed the incidence of axillary nodal micrometastases and induced stage migration on a population based level. Methods Data from the population based Eindhoven Cancer Registry were used on all (n = 17100) women diagnosed with invasive breast cancer in the South-East region of The Netherlands in the period 1994-2005. Results The percentage of patients staged with SNB increased from 0% in 1994 to 62% in 2005. The percentage of patients with micrometastases increased from 1.0% in 1994 to 4.3% in 2005 (P < 0.0001), whereas no significant increase was observed of the proportion of patients with positive axillary lymph nodes. After adjustment for tumor size, age at diagnosis and histology the probability of having a positive axillary lymph node status was 10% higher in period 2003-2005, as compared to period 1994-1996. Furthermore, women diagnosed in the period 2003-2005 had a 3.5 times higher risk of having micrometastases compared to women diagnosed in the period 1994-1996 (i.e., before the introduction of SNB). Conclusion The introduction of SNB in the Southeast region of The Netherlands has led to stage migration, as is reflected by the small but significant increase of the proportion of patients with positive axillary lymph nodes after adjustment for tumor size and age.