Clinical usefulness of the pattern of non-adherence to anti-platelet regimen in stented patients (PARIS) thrombotic risk score to predict long-term all-cause mortality and heart failure hospitalization after percutaneous coronary intervention

• Published in: PloS one Vol. 17; no. 9; p. e0274287
• Main Authors: Akama, Joh, Shimizu, Takeshi, Ando, Takuya, Anzai, Fumiya, Muto, Yuuki, Kimishima, Yusuke, Kiko, Takatoyo, Yoshihisa, Akiomi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Ishida, Takafumi, Takeishi, Yasuchika
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 13.09.2022; Public Library of Science (PLoS)
• Subjects: Acute coronary syndromes; Angina pectoris; Angioplasty; Blood platelets; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Care and treatment; Cholesterol; Complications and side effects; Congestive heart failure; Coronary vessels; Creatinine; Diabetes; Epidemiology; Evaluation; Failure analysis; Hazard assessment; Health hazards; Health risks; Heart attacks; Heart failure; Hemoglobin; Hospitalization; Implants; Laboratories; Medical prognosis; Medical records; Medicine and Health Sciences; Mortality; Observational studies; Patient compliance; Patient outcomes; Patients; Physicians; Platelets; Risk; Risk groups; Statistical analysis; Stent (Surgery); Thrombosis; Japan; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0274287

Background The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score has been proposed to estimate the risk of stent thrombotic events after percutaneous coronary intervention (PCI). However, the prognostic value of the PARIS thrombotic risk score for long term all-cause and cardiac mortalities, as well as hospitalization due to heart failure, has not yet been evaluated. Therefore, the aim of the present study was to evaluate the prognostic value of the PARIS thrombotic risk score for all-cause and cardiac mortalities and hospitalization due to heart failure following PCI. Methods and results Consecutive 1,061 patients who underwent PCI were divided into three groups based on PARIS thrombotic risk score; low- (n = 320), intermediate- (n = 469) and high-risk (n = 272) groups. We followed up on all three groups for all-cause mortality, cardiac mortality and hospitalization due to heart failure. Kaplan-Meier analysis showed that all outcomes were highest in the high-risk group (P < 0.001, P = 0.022 and P < 0.001, respectively). Multivariate Cox proportional hazard analysis, adjusted for confounding factors, showed that the risk of all-cause mortality and hospitalization due to heart failure of the high-risk group were higher than those of the low-risk group (hazard ratios 1.76 and 2.14, P = 0.005 and P = 0.017, respectively). Conclusion The PARIS thrombotic risk score is a significant prognostic indicator for all-cause mortality and hospitalization due to heart failure in patients after PCI.