Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function

• Published in: Diabetes care Vol. 31; no. 8; pp. 1613 - 1614
• Main Authors: Hammer, Sebastiaan, Jonker, Jacqueline T, Lamb, Hildo J, van der Meer, Rutger W, Zondag, Wendy, Sepers, Jan M, de Roos, Albert, Smit, Johannes W.A, Romijn, Johannes A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2008
• Subjects: Adult; Age of Onset; Biological and medical sciences; Blood Glucose - metabolism; Cardiac patients; Cardiovascular disease; Care and treatment; Dextrose; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty Acids, Nonesterified - blood; Glucose; Heart Function Tests; Humans; Hyperglycemia; Hyperglycemia - blood; Hyperglycemia - physiopathology; Infusions, Intravenous; Insulin - administration & dosage; Insulin - blood; Insulin - therapeutic use; Liver - metabolism; Medical sciences; Metabolic diseases; Miscellaneous; Myocardium - metabolism; Nuclear magnetic resonance spectroscopy; Pathophysiology/Complications; Public health. Hygiene; Public health. Hygiene-occupational medicine; Triglycerides; Triglycerides - blood; Triglycerides - metabolism; Type 1 diabetes; Endocrinopathy; Short term; Human; Immunopathology; Nutrition; Hyperglycemic substances; Lipids; Patient; Autoimmune disease; Metabolic diseases; Change; Triglyceride; Hyperglycemia; Type 1 diabetes; Content; Myocardium; Circulatory system; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc08-0513

OBJECTIVE:--To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS--Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10). RESULTS:--Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function. CONCLUSIONS:--Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.