African trypanosomes

African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate import...

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Bibliographic Details
Published inParasites & vectors Vol. 12; no. 1; p. 190
Main Authors Cayla, Mathieu, Rojas, Federico, Silvester, Eleanor, Venter, Frank, Matthews, Keith R
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 29.04.2019
BioMed Central
BMC
Subjects
Africa South of the Sahara - epidemiology
African trypanosomiasis
Animals
Antigens
Biology
Chromosomes
Culture techniques
Disease transmission
Eukaryotes
Gene expression
Genes
Genetic aspects
Genetic engineering
Genomes
Host-Parasite Interactions
Humans
Infections
Insect Vectors - parasitology
Metabolism
Morphology
Motility
New technology
Parasites
Pentamidine
Primer
Proteins
Protozoa
Risk factors
RNA polymerase
Sleeping sickness
Suramin
Technology
Trends
Trypanosoma - classification
Trypanosoma - genetics
Trypanosoma brucei
Trypanosoma brucei brucei - genetics
Trypanosoma brucei brucei - isolation & purification
Trypanosome
Trypanosomiasis
Trypanosomiasis, African - epidemiology
Trypanosomiasis, African - transmission
Tsetse Flies - parasitology
Vector-borne diseases
Africa South of the Sahara
Sub-Saharan Africa
Africa
Trypanosoma brucei
Sleeping sickness
Trypanosome
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Summary:African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in their mammalian host and during passage through their tsetse fly vector. This Primer overviews current research themes focused on these parasites and discusses how these biological insights and the development of new technologies to interrogate gene function are being used in the search for new approaches to control the parasite. The new insights into the biology of trypanosomes in their host and vector highlight that we are in a 'golden age' of discovery for these fascinating parasites.
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ISSN:1756-3305
1756-3305
DOI:10.1186/s13071-019-3355-5