Targeting the Impossible: A Review of New Strategies against Endospores

Endospore-forming bacteria are ubiquitous, and their endospores can be present in food, in domestic animals, and on contaminated surfaces. Many spore-forming bacteria have been used in biotechnological applications, while others are human pathogens responsible for a wide range of critical clinical i...

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Published inAntibiotics (Basel) Vol. 12; no. 2; p. 248
Main Authors Romero-Rodríguez, Alba, Ruiz-Villafán, Beatriz, Martínez-de la Peña, Claudia Fabiola, Sánchez, Sergio
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.01.2023
MDPI
Subjects
Animal health
Antibiotics
Bacteria
bacteriocins
bioactive peptides
Cell division
Disease transmission
Domestic animals
endospore
Environmental conditions
Enzymes
Germination
Health aspects
Health risks
Heat resistance
Infections
Kinases
Metabolism
Natural products
Pathogenesis
Pathogens
Proteins
Review
Signal transduction
Spore-forming bacteria
Spores
germination
bacteriocins
bioactive peptides
endospore
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Summary:Endospore-forming bacteria are ubiquitous, and their endospores can be present in food, in domestic animals, and on contaminated surfaces. Many spore-forming bacteria have been used in biotechnological applications, while others are human pathogens responsible for a wide range of critical clinical infections. Due to their resistant properties, it is challenging to eliminate spores and avoid the reactivation of latent spores that may lead to active infections. Furthermore, endospores play an essential role in the survival, transmission, and pathogenesis of some harmful strains that put human and animal health at risk. Thus, different methods have been applied for their eradication. Nevertheless, natural products are still a significant source for discovering and developing new antibiotics. Moreover, targeting the spore for clinical pathogens such as Clostridioides difficile is essential to disease prevention and therapeutics. These strategies could directly aim at the structural components of the spore or their germination process. This work summarizes the current advances in upcoming strategies and the development of natural products against endospores. This review also intends to highlight future perspectives in research and applications.
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12020248