Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

• Published in: Gynecologic oncology Vol. 146; no. 2; pp. 405 - 415
• Main Authors: Holloway, Robert W., Abu-Rustum, Nadeem R., Backes, Floor J., Boggess, John F., Gotlieb, Walter H., Jeffrey Lowery, W., Rossi, Emma C., Tanner, Edward J., Wolsky, Rebecca J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2017
• Subjects: Adenocarcinoma, Clear Cell - pathology; Adenocarcinoma, Clear Cell - surgery; Carcinoma, Endometrioid - pathology; Carcinoma, Endometrioid - surgery; Carcinosarcoma - pathology; Carcinosarcoma - surgery; Colorimetry; Coloring Agents; Consensus recommendation; Endometrial cancer; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Gynecology; Hematology, Oncology and Palliative Medicine; Humans; Indocyanine Green; Literature review; Lymph Node Excision; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous - pathology; Neoplasms, Cystic, Mucinous, and Serous - surgery; Obstetrics and Gynecology; Organotechnetium Compounds; Pathology & clinical outcomes; Sentinel Lymph Node - pathology; Sentinel Lymph Node Biopsy - methods; Sentinel lymph node mapping; Single Photon Emission Computed Tomography Computed Tomography; Societies, Medical; Spectroscopy, Near-Infrared; Surgical Oncology; Surgical staging; Pathology & clinical outcomes; Literature review; Sentinel lymph node mapping; Endometrial cancer; Surgical staging; Consensus recommendation
• ISSN: 0090-8258; 1095-6859; 1095-6859
• DOI: 10.1016/j.ygyno.2017.05.027

The emphasis in contemporary medical oncology has been “precision” or “personalized” medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology's (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document. Literature-based recommendations for the inclusion of SLN assessment in the treatment of patients with endometrial cancer are presented. This article examines:•History and various techniques of SLN mapping in endometrial cancer•Pathology and clinical outcomes from SLN assessment•Controversies and future directions for research in SLN assessment in endometrial cancer. •SLN mapping compared to staging lymphadenectomy in EC may reduce morbidity.•Literature-based recommendations for the inclusion of SLN assessments are presented.•History and various techniques of SLN mapping in endometrial cancer are described.•Pathology and clinical outcomes from SLN assessment are reviewed.•Controversies and future directions for research in SLN assessment are discussed.