Advances in mechanisms of asthma, allergy, and immunology in 2011

• Published in: Journal of allergy and clinical immunology Vol. 129; no. 2; pp. 335 - 341
• Main Authors: Boyce, Joshua A., MD, Bochner, Bruce, MD, Finkelman, Fred D., PhD, Rothenberg, Marc E., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.02.2012; Elsevier; Elsevier Limited
• Subjects: Age; Allergies; Allergy and Immunology; Animals; Asthma; Asthma - diagnosis; Asthma - immunology; Asthma - therapy; Biological and medical sciences; calcitonin gene-related peptide; Chronic obstructive pulmonary disease, asthma; cyclic AMP; Cytokines; Cytokines - immunology; dendritic cell; Disease Susceptibility; Drug dosages; Dust; facilitated antigen binding; facilitated antigen presentation; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Galactose-α-1,3-galactose; genome-wide association study; Humans; Hypersensitivity - diagnosis; Hypersensitivity - immunology; Hypersensitivity - therapy; Immunoglobulin E - immunology; Immunology; Immunopathology; Immunotherapy; interferon; lipopolysaccharide; Medical sciences; Oxidative stress; Pneumology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Toll-like receptor; toluidine diisothiocyanate; vascular endothelial growth factor; β 3 integrin gene; NADPH; ITGB3; α-Gal; SNP; ORMDL3; Orosomucoid 1–like 3 gene; TDI; Regulatory T; cyclic AMP; slanDC; TLR; facilitated antigen presentation; Toll-like receptor; facilitated antigen binding; GSDMA; Reduced nicotine adenine dinucleotide phosphate; Treg; calcitonin gene-related peptide; interferon; toluidine diisothiocyanate; FAP; DC that expresses the 6-sulfo-LacNAc residue on P-selectin glycoprotein ligand 1; Galactose-α-1,3-galactose; vascular endothelial growth factor; genome-wide association study; Single nucleotide polymorphism; lipopolysaccharide; dendritic cell; DC; Gasdermin A; Allergy; Dyes; Toll like receptor; Neuropeptide; Mechanism; Association; Immunology; Toluidine; Antigen presenting cell; Lipopolysaccharide; Bronchus disease; Obstructive pulmonary disease; Lung disease; Dendritic cell; Immunopathology; Antigen presentation; Respiratory disease; Cytokine; Cyclic AMP; Calcitonin gene related peptide; Asthma; Antigen; Calactose-α-1,3-galactose; Vascular endothelium growth factor; Interferon; Galactose; Genome
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2011.12.968

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from TH 17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.