Antipsychotics' effects on blood levels of cytokines in schizophrenia: A meta-analysis

• Published in: Schizophrenia research Vol. 151; no. 1-3; pp. 43 - 47
• Main Authors: Tourjman, Valérie, Kouassi, Édouard, Koué, Marie-Ève, Rocchetti, Matteo, Fortin-Fournier, Simon, Fusar-Poli, Paolo, Potvin, Stéphane
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Antipsychotic Agents - therapeutic use; Antipsychotic drugs; Biological and medical sciences; Cytokines; Cytokines - blood; Cytokines - therapeutic use; Databases, Bibliographic - statistics & numerical data; Evidence-Based Medicine; Humans; Inflammation; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Schizophrenia; Schizophrenia - blood; Schizophrenia - drug therapy; Schizophrenia; Inflammation; Antipsychotic drugs; Cytokines; Human; Neuroleptic; Psychotropic; Cytokine; Pharmacotherapy; Review; Metaanalysis; Psychosis; Treatment; Antipsychotic
• ISSN: 0920-9964; 1573-2509; 1573-2509
• DOI: 10.1016/j.schres.2013.10.011

Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined. A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment. We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1β and interferon-γ. These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.