Prognostic Role of Cell Blood Count in Chronic Myeloid Neoplasm and Acute Myeloid Leukemia and Its Possible Implications in Hematopoietic Stem Cell Transplantation

• Published in: Diagnostics (Basel) Vol. 12; no. 10; p. 2493
• Main Authors: Mulas, Olga, Mola, Brunella, Madeddu, Clelia, Caocci, Giovanni, Macciò, Antonio, Nasa, Giorgio La
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2022; MDPI
• Subjects: Angiogenesis; Blood cell count; Blood platelets; Blood tests; Bone marrow; Cancer; Care and treatment; Chronic myeloid leukemia; Cytokines; Disease; Health aspects; Hematology; Inflammation; Kinases; Leukemia; lymphocyte-monocyte ratio; Lymphocytes; Medical prognosis; Metastasis; monocyte; Mortality; Mutation; myeloid neoplasms; neutrophil-lymphocyte ratio (NLR); Neutrophils; Pathogenesis; platelets; Prognosis; Review; Stem cell transplantation; Stem cells; Thrombosis; Transplantation; Tumors; Italy; lymphocyte-monocyte ratio; hematopoietic stem cell transplantation; chronic myeloid leukemia; monocyte; neutrophil-lymphocyte ratio (NLR); myeloid neoplasms; prognosis; platelets
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics12102493

Numerous prognostic indexes have been developed in hematological diseases based on patient characteristics and genetic or molecular assessment. However, less attention was paid to more accessible parameters, such as neutrophils, lymphocytes, monocytes, and platelet counts. Although many studies have defined the role of neutrophil-to-lymphocyte or platelet-to-lymphocyte in lymphoid malignancies, few applications exist for myeloid neoplasm or hematopoietic stem cell transplantation procedures. In this review, we synthesized literature data on the prognostic value of count blood cells in myeloid malignancies and hematopoietic stem cell transplantation in the context of classical prognostic factors and clinical outcomes.