Functional analysis of the human perivascular subarachnoid space

• Published in: Nature communications Vol. 15; no. 1; pp. 2001 - 14
• Main Authors: Eide, Per Kristian, Ringstad, Geir
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 59/57; 631/378; 631/443/1338; 692/617; Anatomy; Arteries; Blood vessels; Brain; Cancellous Bone; Cerebral Cortex; Cerebrospinal fluid; Dendrites; Enrichment; Functional analysis; Humanities and Social Sciences; Humans; Hydrocephalus; Intracranial pressure; Magnetic resonance imaging; Medical imaging; multidisciplinary; Neuroimaging; Reserve capacity; Science; Science (multidisciplinary); Subarachnoid space; Subarachnoid Space - diagnostic imaging; Time dependence; Veins & arteries
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-46329-1

The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and consecutive magnetic resonance imaging to investigate features of early (i.e. within 2-3 h after injection) tracer propagation within the subarachnoid space. There is a time-dependent perivascular pattern of enrichment antegrade along the major cerebral artery trunks; the anterior-, middle-, and posterior cerebral arteries. The correlation between time of first enrichment around arteries and early enrichment in nearby cerebral cortex is significant. These observations suggest the existence of a compartmentalized subarachnoid space, where perivascular ensheathment of arteries facilitates antegrade tracer passage towards brain tissue. Periarterial transport is impaired in subjects with reduced intracranial pressure-volume reserve capacity and in idiopathic normal pressure hydrocephalus patients who also show increased perivascular space size. Functional implications of subarachnoid space anatomy remain unclear. Here, the authors show by human in vivo imaging that an intrathecal tracer propagates antegrade along the major cerebral arteries within a perivascular subarachnoid space facilitating tracer passage towards the brain.