Titanium Dioxide–Montmorillonite Nanocomposite as Photoprotective Agent Against Ultraviolet B Radiation-Induced Mutagenesis in Saccharomyces cerevisiae: A Potential Candidate for Safer Sunscreens

• Published in: Journal of pharmaceutical sciences Vol. 103; no. 8; pp. 2539 - 2545
• Main Authors: Paiva, Juliana P., Santos, Bianca A.M.C., Kibwila, Daniel M., Gonçalves, Tula C.W., Pinto, A. Viviana, Rodrigues, Carlos R., Leitão, Alvaro C., Cabral, Lúcio M., Pádula, Marcelo De
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014; Elsevier Limited
• Subjects: Antimutagenic Agents - chemistry; Antimutagenic Agents - pharmacology; Bentonite - chemistry; Bentonite - pharmacology; cerevisiae; clays; layered compounds; montmorillonite; mutagenesis; Mutation - drug effects; Mutation - radiation effects; nanocomposite; Nanocomposites - chemistry; nanostructures, nanotechnology; Saccharomyces cerevisiae; Saccharomyces cerevisiae - drug effects; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - radiation effects; Sunscreening Agents - chemistry; Sunscreening Agents - pharmacology; Titanium - chemistry; Titanium - pharmacology; titanium dioxide; Ultraviolet Rays; UVB; X-ray diffraction; UVB; montmorillonite; layered compounds; clays; nanostructures, nanotechnology; X-ray diffraction; titanium dioxide; nanocomposite; cerevisiae; mutagenesis
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.24057

Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant (deficient) strain. In addition, we developed and characterized a delaminated TiO2-pillared MMT, called the TiO2–MMT nanocomposite (NC), which was also investigated in terms of its photoprotective and mutagenic potential. Overall, our results revealed an interesting TiO2–MMT NC endowed with antimutagenic activity that can be associated to organic sunscreen molecule (ODP) and still maintain its positive effect, whereas its respective PM is unable to grant antimutagenic protection against UVB. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2539–2545, 2014