Influence of Autologous Blood Transfusion on Natural Killer and Lymphokine-Activated Killer Cell Activities in Cancer Surgery
Background and objectives: Immunosuppression associated with blood transfusion may influence postoperative infection rates. It may also affect the prognosis of patients treated surgically for colorectal cancer. To control this effect, study protocols have applied autologous blood donation programs,...
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Published in | Vox sanguinis Vol. 73; no. 4; pp. 237 - 245 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford UK
Blackwell Science Ltd
01.01.1997
Blackwell S. Karger AG |
Subjects | |
Online Access | Get full text |
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Summary: | Background and objectives: Immunosuppression associated with blood transfusion may influence postoperative infection rates. It may also affect the prognosis of patients treated surgically for colorectal cancer. To control this effect, study protocols have applied autologous blood donation programs, which are thought to be immunologically neutral. However, evidence has emerged that blood donation itself might have suppressive effects on natural killer (NK) cell activities. At present, there are no data available on the effects of autologous blood transfusion on NK or lymphokine‐activated killer (LAK) cells. This might be of interest as LAK cells may be active in tumor control. Materials and methods: 26 patients who underwent surgical resection for colorectal cancer, were assigned at random into two groups: (1) autologous blood donation and transfusion, or (2) allogeneic blood transfusion. NK and LAK activities were determined before blood donation, at surgery, and on the 3rd and 8th postoperative day. Results: Blood donation induced a small decrease in NK and LAK activities. The postoperative courses of the two groups differed. In the allogeneic group, NK activity (−50%, p = 0.018) and LAK activity decreased (−60.7%, p = 0.043), whereas in the autologous group the decline in LAK was less pronounced (−33.7%, p = 0.091), and their NK activity even increased (+17.4%, p = 0.315). NK activity was modulated differently in the two study groups (0.0036). Differences in LAK activities were found between the 3rd and 8th day postoperatively (p = 0.354). Conclusions: In patients receiving autologous blood transfusion, postoperative suppressed NK and LAK activities were modulated. This implies that autologous blood transfusion is not immunologically neutral, but has an intrinsic immunomodulatory potential. |
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Bibliography: | ark:/67375/WNG-DKL36FL5-X ArticleID:VOXVOX734_0237 istex:07ADC2E6C69084D3AB85C67F3FBB3EE2235E37E1 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
ISSN: | 0042-9007 1423-0410 |
DOI: | 10.1046/j.1423-0410.1997.7340237.x |