Cholinergic mechanisms in the caudate nucleus

1. Acetylcholine (ACh), and a number of cholinomimetic and cholinolytic agents, have been applied to single neurones of the caudate nucleus, and the effects compared with those produced by stimulation of nucleus ventralis anterior thalami (VA). 2. Neurones responding by excitation following ACh and...

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Bibliographic Details
Published inThe Journal of physiology Vol. 187; no. 1; pp. 163 - 175
Main Authors McLennan, H., York, D. H.
Format Journal Article
LanguageEnglish
Published England The Physiological Society 01.11.1966
Subjects
Acetylcholine - pharmacology
Action Potentials
Animals
Atropine - pharmacology
Cats
Caudate Nucleus - drug effects
Caudate Nucleus - physiology
Electric Stimulation
Iontophoresis
Methacholine Compounds - pharmacology
Neurons - drug effects
Neurons - physiology
Quaternary Ammonium Compounds - pharmacology
Stereotaxic Techniques
Synapses - drug effects
Thalamus - physiology
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Summary:1. Acetylcholine (ACh), and a number of cholinomimetic and cholinolytic agents, have been applied to single neurones of the caudate nucleus, and the effects compared with those produced by stimulation of nucleus ventralis anterior thalami (VA). 2. Neurones responding by excitation following ACh and VA stimulation, and others depressed by both ACh and VA stimulation have been observed. The two types of cell are located in different regions of the nucleus. 3. Both types of ACh effect, and the responses to VA stimulation, are prevented by atropine. 4. Taken with the earlier observation that the release of ACh from the caudate can be enhanced by VA stimulation, it has been suggested that the present results indicate a final cholinergic link in the pathway from VA to caudate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1966.sp008080