[-20-^3H]佛波醇-12-肉豆蔻酯-13-乙酯的合成

用MnO2将佛波醇-12-肉豆蔻酯-13-乙酯氧化，然后利用新制的NaB^3H4氚化还原合成[20-^3H]佛波醇-12-肉豆蔻酯-13-乙酯。所得产物经HPLC纯化后放化纯度〉98％，其比活度达0．654TBq／g。纯化产物在-20℃放置90天仍保持稳定。本法简单易行，标记过程中也不产生异构体。...

Full description

Saved in:
Bibliographic Details
Published inTong wei su Vol. 18; no. 3; pp. 153 - 156
Main Author 吴久伟 廖莎 蔡晓冬 沈德存
Format Journal Article
LanguageChinese
Published 中国原子能科学研究院,同位素研究所,北京,102413 2005
Subjects
[-20-^3H]佛波醇-12-肉豆蔻酯-13-乙酯
NaB^3H4
氚化还原
[20-3H]佛波醇-12-肉豆蔻酯-13-乙酯
氚化还原
NaB3H4
Online AccessGet full text
ISSN1000-7512
DOI10.3969/j.issn.1000-7512.2005.03.006

Cover

More Information
Summary:用MnO2将佛波醇-12-肉豆蔻酯-13-乙酯氧化，然后利用新制的NaB^3H4氚化还原合成[20-^3H]佛波醇-12-肉豆蔻酯-13-乙酯。所得产物经HPLC纯化后放化纯度〉98％，其比活度达0．654TBq／g。纯化产物在-20℃放置90天仍保持稳定。本法简单易行，标记过程中也不产生异构体。
Bibliography:11-2566/TL
[-20-^3H]phorbol-12-myristate-13-acetate
NaB^3 H4
tritiated reduction
R817-33
[-20-^3H]phorbol-12-myristate-13-acetate; tritiated reduction; NaB^3 H4
O628.11
ISSN:1000-7512
DOI:10.3969/j.issn.1000-7512.2005.03.006