The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

• Published in: Oxidative medicine and cellular longevity Vol. 2016; no. 2016; pp. 1 - 13
• Main Authors: Olguin, Hugo Juarez, Guzman, David Calderon, Garcia, Ernestina Hernandez, Mejia, Gerardo Barragan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Animals; Antidepressive Agents - pharmacology; Biosynthesis; Dopamine; Dopamine - chemistry; Dopamine - metabolism; Drug therapy; Endocrine System - drug effects; Endocrine System - metabolism; Enzymes; Gene therapy; Health aspects; Humans; Immunoglobulins; Kinases; Metabolism; Metabolites; Nervous system diseases; Neurons; Neuroprotective Agents - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Physiological aspects; Proteins; Receptors, Dopamine - metabolism; Review; Mexico
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2016/9730467

Dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dysfunction of the dopamine system has been implicated in different nervous system diseases. The level of dopamine transmission increases in response to any type of reward and by a large number of strongly additive drugs. The role of dopamine dysfunction as a consequence of oxidative stress is involved in health and disease. Introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present review focuses on the therapeutic potential of antioxidant compounds as a coadjuvant treatment to conventional neurological disorders is discussed.