Histopathological Studies of Aortic Dissection in Streptozotocin-Induced Diabetic APA Hamsters

• Published in: Experimental Animals Vol. 54; no. 4; pp. 363 - 367
• Main Authors: HORIUCHI, Keiko, TAKATORI, Atsushi, INENAGA, Toshiaki, OHTA, Etsuko, ISHII, Yoshiyuki, KYUWA, Shigeru, YOSHIKAWA, Yasuhiro
• Format: Journal Article
• Language: English
• Published: Japan Japanese Association for Laboratory Animal Science 01.07.2005
• Subjects: Aneurysm, Dissecting - etiology; Aneurysm, Dissecting - pathology; Animals; Aorta, Thoracic - metabolism; Aorta, Thoracic - pathology; Aortic Aneurysm, Thoracic - etiology; Aortic Aneurysm, Thoracic - pathology; aortic dissection; APA hamster; Biomarkers - metabolism; Blood Glucose - analysis; Cholesterol - blood; Cricetinae; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - pathology; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; Male; Mesocricetus; Streptozocin; streptozotocin; Thrombosis - complications; Thrombosis - pathology; Triglycerides - blood
• ISSN: 1341-1357; 1881-7122
• DOI: 10.1538/expanim.54.363

Syrian hamsters of the APA strain (APA hamsters) are known to show continuous diabetes accompanied by its complications, such as glomerulosclerosis and atherosclerosis, following a single injection of streptozotocin (SZ). Recently, we observed Stanford type B aortic dissection in three diabetic APA hamsters and histopathological analysis was performed. The histopathologic observations in the false lumen, such as proliferation of granulation tissues, neointima and pseudoneointima, corresponded to the non-thrombosed type of human aortic dissection, and blood clots of the thrombosed type were similar to the remodeling structures of aortic dissection found in human cases. Thus, this model may be useful for investigating the etiology and pathogenesis of aortic dissection accompanying diabetes mellitus in humans.