Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice

• Published in: BioMed research international Vol. 2018; no. 2018; pp. 1 - 8
• Main Author: Bae, Ju Yong
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acyl-CoA oxidase; Adipocytes; Adipose tissue; Adipose Tissue, Brown - metabolism; Adipose tissues; Aerobics; AMP; AMP-activated protein kinase; Animals; Biomedical research; Biosynthesis; Body fat; Cholesterol; Diet; Diet, High-Fat - adverse effects; Endocrinology; Exercise; Fitness equipment; Glucose; High fat diet; Insulin resistance; Kinases; Lipase; Lipids; Male; Metabolism; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; Nerve Growth Factors - metabolism; Nutrition research; Obesity; Obesity - metabolism; Physical Conditioning, Animal - physiology; Physical fitness; Plasma; Protein kinases; Proteins; Studies; Therapeutic applications; Tissues; Type 2 diabetes; Weight control
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2018/6283932

Upregulated meteorin-like (Metrnl) protein in peripheral tissues because of exercise-induced increases in intramuscular Metrnl may effectively alleviate obesity by improving metabolism in whole-body tissues. The objective was to analyse the effects of regular treadmill exercise on Metrnl levels in muscle and peripheral tissues of chronic high-fat diet- (HFD-) induced obese mice. Forty-eight-week-old male C57BL/6 mice were first divided equally into normal-diet (CO) and high-fat diet (HF) groups. Following 16 weeks of a HFD, each group was again split equally into control (CO, HF) and training groups (COT, HFT). The HFT group expressed significantly higher phospho-AMP-activated protein kinase (AMPK), AMPK activity, and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) in muscle tissue than the HF group (p<0.05). Similar to muscle energy sensing network protein levels, the HFT group also expressed significantly higher muscle, plasma, and adipose tissue Metrnl (p<0.05). Moreover, regular exercise increased acyl-CoA oxidase 1 (ACOX-1) and monoglyceride lipase (MGL) expression in adipose tissue (p<0.05) and significantly decreased abdominal fat mass (p<0.05). This study suggests that exercise-induced muscle Metrnl effectively reduces fat accumulation through the increase of Metrnl in adipose tissue, which may be a therapeutic target for chronic obesity.