Hematolymphopoietic and inflammatory cytokines in neural development

It is now clear that cytokines traditionally viewed as immune modulators participate in inflammatory responses within the adult nervous system. However, in the developing nervous system hematolymphopoietic cytokines also play a role unrelated to neural–immune interactions. Instead, many of these fac...

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Bibliographic Details
Published inTrends in neurosciences (Regular ed.) Vol. 20; no. 8; pp. 357 - 365
Main Authors Mehler, Mark F., Kessler, John A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.08.1997
Elsevier Science
Elsevier Sequoia S.A
Subjects
Animals
Biological and medical sciences
colony-stimulating factors
Cytokines - physiology
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Hematinics - metabolism
Immunity (Disease)
interferons
interleukins
leukemia inhibitory factor
Morphogenesis - immunology
Nervous system
Nervous System - embryology
Nervous System - immunology
Neurology
progenitor cells
transforming growth factor b
Vertebrates: nervous system and sense organs
progenitor cells
interferons
leukemia inhibitory factor
colony-stimulating factors
transforming growth factor b
interleukins
Ripening
Development
Hemopoietin
Neuron
Review
Cytokine
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Summary:It is now clear that cytokines traditionally viewed as immune modulators participate in inflammatory responses within the adult nervous system. However, in the developing nervous system hematolymphopoietic cytokines also play a role unrelated to neural–immune interactions. Instead, many of these factors subserve primary regulatory functions related both to the morphogenesis and to the cellular maturation of the central and peripheral nervous systems. This article focuses specifically on cytokine actions in neural development.
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ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(96)01045-4