Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study

• Published in: Journal of perinatology Vol. 33; no. 2; pp. 126 - 133
• Main Authors: Morris, B H, Tyson, J E, Stevenson, D K, Oh, W, Phelps, D L, O'Shea, T M, McDavid, G E, Van Meurs, K P, Vohr, B R, Grisby, C, Yao, Q, Kandefer, S, Wallace, D, Higgins, R D
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.02.2013
• Subjects: Bilirubin; Bilirubin - blood; Birth weight; Birth weight, Low; Care and treatment; Children; Childrens health; Chronology; Devices; Equipment and supplies; Female; Follow-Up Studies; Health aspects; Hospital Mortality; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Infants; Infants (Newborn); Jaundice, Neonatal - diagnosis; Jaundice, Neonatal - mortality; Jaundice, Neonatal - therapy; Light emitting diodes; Light therapy; Long-term effects; Low birth weight; Male; Medical equipment; Neonatal care; Neonates; Newborn babies; Observational studies; Patient outcomes; Pediatrics; Phototherapy; Phototherapy - adverse effects; Phototherapy - instrumentation; Phototherapy - methods; Physiological apparatus; Physiological aspects; Premature babies; Premature birth; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome; United States; United States > US
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2012.39

Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices. This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24±12 h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n=1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined. In the first 24 h, the adjusted absolute (mean (±s.d.)) and relative (%) decrease in TSB (mg dl(-1)) were: light-emitting diodes (LEDs) -2.2 (±3), -22%; Spotlights -1.7 (±2), -19%; Banks -1.3 (±3), -8%; Blankets -0.8 (±3), -1%; (P<0.0002). Some findings at 18 to 22 months differed between groups. LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation.