Transcerebral net exchange of vasoactive peptides and catecholamines during lipopolysaccharide-induced systemic inflammation in healthy humans

The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg −1 ) induces any changes in the transcerebral net exchange of t...

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Published inCanadian journal of physiology and pharmacology Vol. 96; no. 3; pp. 313 - 316
Main Authors Berg, Ronan M.G, Taudorf, Sarah, Bailey, Damian M, Dahl, Rasmus H, Lundby, Carsten, Møller, Kirsten
Format Journal Article
LanguageEnglish
Published Canada NRC Research Press 01.03.2018
Canadian Science Publishing NRC Research Press
Subjects
Amines
Calcitonin
Calcitonin gene-related peptide
Catecholamines
Cerebral blood flow
CGRP
Endothelin 1
endothéline-1
endotoxemia
endotoxémie
epinephrine
Health aspects
Inflammation
Inflammatory response
Intravenous administration
Lipopolysaccharides
norepinephrine
Peptides
Perfusion
Pharmacology
Physiology
Vasoactive agents
Vasoconstriction
épinéphrine
norepinephrine
endotoxémie
endotoxemia
épinéphrine
endothéline-1
epinephrine
endothelin-1
CGRP
calcitonin-gene related peptide
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Summary:The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg −1 ) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety–Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP, and catecholamines by the Fick principle in 12 volunteers before and after LPS infusion. The cerebrovascular release of ET-1 was enhanced, whereas the transcerebral net exchange of CGRP and catecholamines was unaffected. Our findings thus point towards locally produced ET-1 within the cerebrovasculature as a contributor to cerebral vasoconstriction after LPS infusion.
Bibliography:ObjectType-Article-2
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ISSN:0008-4212
1205-7541
DOI:10.1139/cjpp-2017-0266