Preclinical Studies and Translational Applications of Intracerebral Hemorrhage

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 18
• Main Authors: Huang, Lijie, Ruan, Linhui, Xu, Zhu, Lin, Xiao, Ni, Haoqi, Nyanzu, Mark, Siaw-Debrah, Felix, ZhuGe, Qichuan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Animals; Apoptosis; Biomedical research; Blood; Cell- and Tissue-Based Therapy; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - physiopathology; Cerebral Hemorrhage - therapy; Clinical trials; Drugs; Edema; Genetic aspects; Genetic translation; Health aspects; Humans; Inflammation; Intracerebral hemorrhage; Laboratories; Medical prognosis; Production increases; Review; Science; Studies; Theranostic Nanomedicine; Translational Medical Research
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2017/5135429

Intracerebral hemorrhage (ICH) which refers to bleeding in the brain is a very deleterious condition with high mortality and disability rate. Surgery or conservative therapy remains the treatment option. Various studies have divided the disease process of ICH into primary and secondary injury, for which knowledge into these processes has yielded many preclinical and clinical treatment options. The aim of this review is to highlight some of the new experimental drugs as well as other treatment options like stem cell therapy, rehabilitation, and nanomedicine and mention some translational clinical applications that have been done with these treatment options.