The role of neurotrophic factors in regulating the development of inner ear innervation

Several neurotrophins and their receptors regulate the survival of vestibular and cochlear neurons and probably also the efferent and autonomic neurons that innervate the inner ear. Mice lacking either brain-derived neurotrophic factor (BDNF) or its associated receptor, TrkB, lose all innervation to...

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Published inTrends in neurosciences (Regular ed.) Vol. 20; no. 4; pp. 159 - 164
Main Authors Fritzsch, B., Silos-Santiago, I., Bianchi, L.M., Fariñas, I.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.1997
Elsevier Science
Elsevier Sequoia S.A
Subjects
Animals
Biological and medical sciences
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Ear, Inner - growth & development
Ear, Inner - innervation
Ears & hearing
Fundamental and applied biological sciences. Psychology
Mice
Nerve Growth Factors - physiology
Neurology
Space life sciences
Vertebrates: nervous system and sense organs
Neurotrophic factor
Vertebrata
Mammalia
Mouse
Innervation
Rodentia
Development
Review
Inner ear
Organ of hearing
Non-programmatic
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Summary:Several neurotrophins and their receptors regulate the survival of vestibular and cochlear neurons and probably also the efferent and autonomic neurons that innervate the inner ear. Mice lacking either brain-derived neurotrophic factor (BDNF) or its associated receptor, TrkB, lose all innervation to the semicircular canals and have reduced innervation of the outer hair cells in the apical and middle turns of the cochlea. Mice lacking neurotrophin-3 (NT-3) or its receptor,TrkC, lose many spiral ganglion cells predominantly in the basal turn of the cochlea. Nerve fibers from spiral ganglion cells in the middle turn extend to inner hair cells of the base. In mice lacking both BDNF and NT-3, or both TrkB and TrkC, there is a complete loss of innervation to the inner ear. Thus, these two neurotrophins and their associated receptors have been shown to be absolutely necessary for the normal development of afferent innervation of the inner ear. Current research efforts are testing the therapeutic potential for neurotrophins to treat hearing loss.
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ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(96)01007-7