Broad-spectrum antimicrobial epiphytic and endophytic fungi from marine organisms: isolation, bioassay and taxonomy

• Published in: Marine drugs Vol. 7; no. 2; pp. 97 - 112
• Main Authors: Zhang, Yi, Mu, Jun, Feng, Yan, Kang, Yue, Zhang, Jia, Gu, Peng-Juan, Wang, Yu, Ma, Li-Fang, Zhu, Yan-Hua
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.04.2009; Molecular Diversity Preservation International
• Subjects: Alternaria alternata; Animals; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; antimicrobial activity; Bacteria - drug effects; Candida albicans - drug effects; DNA, Ribosomal Spacer - genetics; Epi- and endophytic; Eukaryota - microbiology; Fungi - classification; Fungi - cytology; Fungi - genetics; Fungi - isolation & purification; Fungi - metabolism; Fusarium oxysporum; Invertebrates - microbiology; Marine; Marine Biology; marine derived fungi; Molecular Sequence Data; Penicillium glabrum; Phylogeny; Symbiosis - physiology; taxonomy; Epi- and endophytic; antimicrobial activity; taxonomy; marine derived fungi
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md7020097

In the search for new marine derived antibiotics, 43 epi- and endophytic fungal strains were isolated from the surface or the inner tissue of different marine plants and invertebrates. Through preliminary and secondary screening, 10 of them were found to be able to produce broad-spectrum antimicrobial metabolites. By morphological and molecular biological methods, three active strains were characterized to be Penicillium glabrum, Fusarium oxysporum, and Alternaria alternata.