Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor

• Published in: Evidence-based complementary and alternative medicine Vol. 2017; no. 2017; pp. 1 - 9
• Main Authors: Hu, Yun-xia, Yu, Xi-zhong, Xu, Jian Ya, Zhao, Yan-hua, Bai, Yu, Zhao, Zhi-qiang
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Age; Anorexia; Atractylodes; Cachexia; Calcium; Cancer; Cell growth; Chemical properties; Chinese medicine; Clinical medicine; Emptying; Endocrinology; Fluorides; Gastric emptying; Gastrointestinal system; Ghrelin; Growth hormone; Growth hormones; Health aspects; Hormone receptors; Laboratories; Medicinal plants; Motility; Myosin; Phosphatase; Phosphorylation; Physiological aspects; Physiology; Phytochemicals; Rhizomes; Rodents; Smooth muscle; United States > US; China
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2017/2186798

Atractylodin is one of the main constituents in the rhizomes of Atractylodes lancea Thunb., being capable of treating cancer cachexia-anorexia and age-related diseases as an agonist of growth hormone secretagogue receptor (GHSR). GHSR was herein expressed in human gastric smooth muscle cells (HGSMCs) and activated by ghrelin receptor agonist L-692,585. Like L-692,585, atractylodin also increased Ca2+ and enhanced the phosphorylation of myosin light chain (MLC) through GHSR in HGSMCs. In addition, atractylodin promoted gastric emptying and MLC phosphorylation in the gastric antrum of mice also through GHSR. Collectively, atractylodin can activate GHSR in gastric smooth muscle, as a potential target in clinical practice.