Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms
We analyzed and compared genomes of Extended Spectrum Beta-Lactamase (ESBL)-producing from pigs and pig farm workers at 116 farms in Vietnam. Analyses revealed the presence of , , , , , , , , and in both hosts. Most strains from pigs contained quinolones ( ) and colistin resistance genes ( -1 and -3...
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Published in | Antibiotics (Basel) Vol. 10; no. 10; p. 1165 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
25.09.2021
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | We analyzed and compared genomes of Extended Spectrum Beta-Lactamase (ESBL)-producing
from pigs and pig farm workers at 116 farms in Vietnam. Analyses revealed the presence of
,
,
,
,
,
,
,
, and
in both hosts. Most strains from pigs contained quinolones (
) and colistin resistance genes (
-1 and
-3). Isolates predominantly harbored more than one plasmid replicon and some harbored plasmid replicons on the same contigs as the ESBL genes. Five strains from farm workers of ST38 (2), ST69 (1), and ST1722 (2) were classified as either uropathogenic
(UPEC
)/extraintestinal pathogenic
(ExPEC
) or UPEC
, and the remaining were genetically distinct commensals. A high heterogeneity was found among the ESBL-producing
from pigs and workers, with most isolates belonging to unrelated phylogroups, serogroups, and sequence types with >4046 Single-Nucleotide Polymorphisms-(SNPs). In comparing the genomes of pig isolates to those from humans, it appeared that ESBL-producing
in workers did not predominantly originate from pigs but were rather host-specific. Nevertheless, the occurrence of ESBL-producing
carrying plasmid-mediated colistin and quinolone resistance genes in pigs could represent a potential source for horizontal transmission to humans through food rather than direct contact. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2079-6382 2079-6382 |
DOI: | 10.3390/antibiotics10101165 |