Long Noncoding RNAs as Biomarkers in Cancer

Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development...

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Bibliographic Details
Published inDisease markers Vol. 2017; no. 2017; pp. 1 - 14
Main Authors Bolha, Luka, Glavač, Damjan, Ravnik-Glavač, Metka
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Subjects
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Body fluids
Cancer
Carcinogenesis
Cell-Free Nucleic Acids - blood
Cell-Free Nucleic Acids - genetics
Chromatin remodeling
Deregulation
Diagnosis
Epigenesis, Genetic
Genetic aspects
Genetic markers
Health aspects
Humans
Medical diagnosis
Neoplasms - blood
Neoplasms - genetics
Non-coding RNA
Oncology, Experimental
Patients
Prognosis
Review
Ribonucleic acid
RNA
RNA, Long Noncoding - blood
RNA, Long Noncoding - genetics
Tissues
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Summary:Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detection of cancer-associated lncRNAs in body fluids of cancer patients has proven itself as an especially valuable method to effectively diagnose cancer. Cancer diagnosis and prognosis employing circulating lncRNAs are preferential when compared to classical biopsies of tumor tissues, especially due to their noninvasiveness, and have great potential for routine usage in clinical practice. Thus, this review focuses on summarizing the perspectives of lncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients.
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Academic Editor: Wai K. Chu
ISSN:0278-0240
1875-8630
1875-8630
DOI:10.1155/2017/7243968