Expert consensus on vaccination in patients with inflammatory bowel disease in Japan

• Published in: Journal of gastroenterology Vol. 58; no. 2; pp. 135 - 157
• Main Authors: Ishige, Takashi, Shimizu, Toshiaki, Watanabe, Kenji, Arai, Katsuhiro, Kamei, Koichi, Kudo, Takahiro, Kunisaki, Reiko, Tokuhara, Daisuke, Naganuma, Makoto, Mizuochi, Tatsuki, Murashima, Atsuko, Inoki, Yuta, Iwata, Naomi, Iwama, Itaru, Koinuma, Sachi, Shimizu, Hirotaka, Jimbo, Keisuke, Takaki, Yugo, Takahashi, Shohei, Cho, Yuki, Nambu, Ryusuke, Nishida, Daisuke, Hagiwara, Shin-ichiro, Hikita, Norikatsu, Fujikawa, Hiroki, Hosoi, Kenji, Hosomi, Shuhei, Mikami, Yohei, Miyoshi, Jun, Yagi, Ryusuke, Yokoyama, Yoko, Hisamatsu, Tadakazu
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.02.2023; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Adalimumab; Adult; BCG; BCG vaccines; Breast feeding; Care and treatment; Cervical cancer; Child; Colorectal Surgery; Consensus; Coronaviruses; COVID-19; Decision making; Female; Gastroenterology; Gastrointestinal diseases; Hepatology; Humans; Immune response; Immunosuppressive agents; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - drug therapy; Intestine; Japan; Medical colleges; Medicine; Medicine & Public Health; Original Article—Alimentary Tract; Original —Alimentary Tract; Patients; Pediatrics; Pregnancy; Risk factors; Surgical Oncology; Tofacitinib; Vaccination; Vaccination - adverse effects; Vaccines; Japan; Immunization; Vaccine-preventable disease; Ulcerative colitis; Crohn’s disease
• ISSN: 0944-1174; 1435-5922; 1435-5922
• DOI: 10.1007/s00535-022-01953-w

Immunosuppressive therapies can affect the immune response to or safety of vaccination in patients with inflammatory bowel disease (IBD). The appropriateness of vaccination should be assessed prior to the initiation of IBD treatment because patients with IBD frequently undergo continuous treatment with immunosuppressive drugs. This consensus was developed to support the decision-making process regarding appropriate vaccination for pediatric and adult patients with IBD and physicians by providing critical information according to the published literature and expert consensus about vaccine-preventable diseases (VPDs) [excluding cervical cancer and coronavirus disease 2019 (COVID-19)] in Japan. This consensus includes 19 important clinical questions (CQs) on the following 4 topics: VPDs (6 CQs), live attenuated vaccines (2 CQs), inactivated vaccines (6 CQs), and vaccination for pregnancy, childbirth, and breastfeeding (5 CQs). These topics and CQs were selected under unified consensus by the members of a committee on intractable diseases with support by a Health and Labour Sciences Research Grant. Physicians should provide necessary information on VPDs to their patients with IBD and carefully manage these patients’ IBD if various risk factors for the development or worsening of VPDs are present. This consensus will facilitate informed and shared decision-making in daily IBD clinical practice.