Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production

• Published in: Bioscience, biotechnology, and biochemistry Vol. 72; no. 10; pp. 2775 - 2778
• Main Authors: Noshita, T.(Aomori Univ. (Japan)), Funayama, S, Hirakawa, T, Kidachi, Y, Ryoyama, K
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.10.2008; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Animals; Biological and medical sciences; Cell Line; COMPOSE HETEROCYCLIQUE; COMPUESTOS HETEROCICLICOS; denudatin; EXTRACTOS VEGETALES; EXTRAIT D'ORIGINE VEGETALE; FRUIT; Fruit - chemistry; Fruit - growth & development; FRUTO; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Enzymologic - drug effects; HETEROCYCLIC COMPOUNDS; INHIBICION; INHIBITION; Lignans - chemistry; Lignans - classification; Lignans - isolation & purification; Lignans - pharmacology; machilin G; macrophage; MAGNOLIA; Magnolia - chemistry; Magnolia - growth & development; Magnolia denudata; Mice; Molecular Structure; NITRIC OXIDE; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; nitric oxide synthase; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; OXIDO NITRICO; OXYDE NITRIQUE; PLANT EXTRACTS; RODENTIA; denudatin; Magnolia denudata; Fruit; Enzyme; Magnolia; Nitric-oxide synthase; Dicotyledones; Magnoliaceae; Nitric oxide; Angiospermae; Production; machilin G; Spermatophyta; Oxidoreductases; Inhibition; nitric oxide synthase; Macrophage
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.80327

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.