Draft Genome Sequence of Streptomyces globisporus C-1027, Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein

Streptomyces globisporus C-1027 is the producer of antitumor antibiotic C-1027, a nine-membered enediyne-containing compound. Here we present a draft genome sequence of S. globisporus C-1027 containing the intact biosynthetic gene cluster for this antibiotic. The genome also carries numerous sets of...

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Bibliographic Details
Published inJournal of Bacteriology Vol. 194; no. 15; p. 4144
Main Authors Wang, Lifei, Wang, Songmei, He, Qing, Yu, Tengfei, Li, Qinglian, Hong, Bin
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.2012
Subjects
Antibiotics
Antineoplastic Agents - metabolism
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Biosynthesis
Biosynthetic Pathways - genetics
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Enediynes - metabolism
Fundamental and applied biological sciences. Psychology
Genes
Genome Announcements
Genome, Bacterial
Genomes
Metabolites
Microbiology
Miscellaneous
Molecular Sequence Data
Multigene Family
nucleotide sequences
secondary metabolites
Sequence Analysis, DNA
Streptomyces - genetics
Streptomyces - isolation & purification
Streptomyces - metabolism
Streptomyces globisporus
Actinomycetales
Antineoplastic agent
Streptomyces globisporus
Antibiotic
Streptomycetaceae
Nucleotide sequence
Bacteria
Actinomycetes
Diynic compound
Enynic compound
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Summary:Streptomyces globisporus C-1027 is the producer of antitumor antibiotic C-1027, a nine-membered enediyne-containing compound. Here we present a draft genome sequence of S. globisporus C-1027 containing the intact biosynthetic gene cluster for this antibiotic. The genome also carries numerous sets of genes for the biosynthesis of diverse secondary metabolites.
Bibliography:http://dx.doi.org/10.1128/JB.00797-12
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L.W. and S.W. contributed equally to this article.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/JB.00797-12