The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Highlights • Neurotrauma can cause a prolonged inflammatory response with primed microglia. • Primed microglia are more susceptible to future insults; both internal and external. • Neurotraumatic events can also induce structural and functional damage to the gut. • Damaged gut increases intestinal p...

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 66; pp. 31 - 44
Main Authors Sundman, Mark H, Chen, Nan-kuei, Subbian, Vignesh, Chou, Ying-hui
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.11.2017
Subjects
Allergy and Immunology
Chronic Traumatic Encephalopathy
Concussion
Gut
Gut-brain axis
Intestinal dysfunction
Microbiota
Microglia
Neurodegenerative disease
Neuroinflammation
Psychiatry
Traumatic Brain Injury
Microbiota
Traumatic Brain Injury
Chronic Traumatic Encephalopathy
Concussion
Gut-brain axis
Gut
Neurodegenerative disease
Neuroinflammation
Intestinal dysfunction
Microglia
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Summary:Highlights • Neurotrauma can cause a prolonged inflammatory response with primed microglia. • Primed microglia are more susceptible to future insults; both internal and external. • Neurotraumatic events can also induce structural and functional damage to the gut. • Damaged gut increases intestinal permeability, prompting a systemic immune response. • Microglia are peripherally influenced to exacerbate ongoing CNS inflammation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.05.009