Plasma hydrazine concentrations in man after isoniazid and hydralazine administration

By using a specific sensitive stable-isotope dilution gas chromatography-mass spectrometry (GC-MS) assay, hydrazine was detected in the plasma of eight healthy male volunteer subjects taking isoniazid (300 mg daily) for 2 weeks. Accumulation of hydrazine occurred in slow-acetylator phenotypes. Hydra...

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Published inHuman & experimental toxicology Vol. 4; no. 2; pp. 195 - 202
Main Authors Blair, I A, Mansilla Tinoco, R, Brodie, M J, Clare, R A, Dollery, C T, Timbrell, J A, Beever, I A
Format Journal Article
LanguageEnglish
Published England 01.03.1985
Subjects
Acetylation
Adult
Gas Chromatography-Mass Spectrometry
Humans
Hydralazine - administration & dosage
Hydralazine - metabolism
Hydrazines - blood
Hypertension - blood
Hypertension - drug therapy
Isoniazid - administration & dosage
Isoniazid - metabolism
Male
Phenotype
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Summary:By using a specific sensitive stable-isotope dilution gas chromatography-mass spectrometry (GC-MS) assay, hydrazine was detected in the plasma of eight healthy male volunteer subjects taking isoniazid (300 mg daily) for 2 weeks. Accumulation of hydrazine occurred in slow-acetylator phenotypes. Hydrazine was also detected in the plasma of eight out of 14 hypertensive patients treated chronically with hydralazine (200 mg daily). However, the concentrations of hydrazine observed were much lower than in the isoniazid study and were close to the limit of detection. As hydrazine is hepatotoxic, mutagenic and carcinogenic in animals, its presence in human plasma has important toxicological implications.
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ISSN:0144-5952
0960-3271
DOI:10.1177/096032718500400210