Blackberry and Blueberry Anthocyanin Supplementation Counteract High-Fat-Diet-Induced Obesity by Alleviating Oxidative Stress and Inflammation and Accelerating Energy Expenditure

• Published in: Oxidative medicine and cellular longevity Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Zhang, Min, Guo, Xueqi, Gao, Yufang, Wu, Tao, Gong, Lingxiao
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Animals; Anthocyanin; Anthocyanins - therapeutic use; Blueberry Plants - chemistry; Body weight; Cholesterol; Diet; Discriminant analysis; Energy Metabolism - drug effects; Esters; Food; Fruits; Gene expression; Glutathione Peroxidase - metabolism; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Interleukin-6 - metabolism; Laboratory animals; Lipid Metabolism - drug effects; Lipids; Liraglutide; Liver; Lorcaserin; Male; Mass spectrometry; Medical research; Medicine, Experimental; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Nutrition research; Obesity; Obesity - drug therapy; Obesity - metabolism; Oxidative stress; Oxidative Stress - drug effects; Principal components analysis; Rodents; Rubus - chemistry; Superoxide; Superoxide Dismutase - metabolism; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Weight control; China; United States > US
• ISSN: 1942-0900; 1942-0994; 1942-0994
• DOI: 10.1155/2018/4051232

Many studies indicate that an anthocyanin-rich diet has beneficial effects preventing metabolic disease. In the present study, the molecular mechanism underlying the antiobesity effect of consuming blackberry anthocyanins (BLA) and blueberry anthocyanins (BBA) was investigated in high-fat-diet- (HFD-) fed C57BL/6 mice. Sixty mice were administered a low-fat diet (LFD), a HFD, or a HFD plus orlistat, and BLA or BBA in their daily food for 12 weeks. As a result, the consumption of BLA and BBA inhibited body weight gain by 40.5% and 55.4%, respectively, in HFD-fed mice. The BLA and BBA treatments markedly reduced serum and hepatic lipid levels and significantly increased hepatic superoxide dismutase and glutathione peroxidase activities. In addition, the treatments effectively increased fecal acetate and butyrate levels and significantly attenuated expression of tumor necrosis factor TNF-α, interleukin-6, and nuclear factor-kappaB genes. Moreover, gas chromatography time-of-flight mass spectroscopy results suggested that BLA and BBA significantly affected the hepatic lipid and glucose metabolic pathways, including glycerophospholipid metabolism, glutathione metabolism, and the insulin-signaling pathway. Therefore, BLA and BBA ameliorated diet-induced obesity by alleviating oxidative stress and inflammation and accelerating energy expenditure.