hKAP1.6 and hKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins are Expressed in the Hair Follicle Cortex

Hair fiber differentiation involves the expression of both hair keratin intermediate filament proteins and their associated proteins, termed keratin-associated proteins. In this study, cDNA clones encoding two novel keratin-associated proteins were isolated from human hair follicle mRNA. The predict...

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Published inJournal of investigative dermatology Vol. 118; no. 2; pp. 226 - 231
Main Authors Shimomura, Yutaka, Aoki, Noriaki, Ito, Masaaki, Rogers, Michael A., Langbein, Lutz, Schweizer, Jürgen
Format Journal Article
LanguageEnglish
Published Danvers, MA Elsevier Inc 01.02.2002
Nature Publishing
Elsevier Limited
Subjects
Amino Acid Sequence - genetics
Base Sequence - genetics
Biological and medical sciences
Dermatology
DNA, Complementary - isolation & purification
Hair Follicle - metabolism
human gene
Humans
In Situ Hybridization
Investigative techniques, diagnostic techniques (general aspects)
keratin
keratin-associated protein
Keratins - genetics
Keratins - metabolism
Keratins, Hair-Specific
Medical sciences
Molecular Sequence Data
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Sequence Homology, Amino Acid
Sulfur - metabolism
Tissue Distribution
keratin
human gene
keratin-associated protein
in situ hybridization
Human
Keratin
Gene
Scalp
Hair follicle
Sulfur
Protein
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Summary:Hair fiber differentiation involves the expression of both hair keratin intermediate filament proteins and their associated proteins, termed keratin-associated proteins. In this study, cDNA clones encoding two novel keratin-associated proteins were isolated from human hair follicle mRNA. The predicted amino acid sequence derived from these clones revealed that these proteins represent members of the human keratin-associated protein 1 family. They show strong sequence homology to two previously described keratin-associated protein 1 family members hKAP1.1 A and hKAP1.1B. We have called these new proteins hKAP1.6 and hKAP1.7, respectively. RNA in situ hybridization studies of human anagen hair follicles using a conserved probe for these four keratin-associated protein 1 members demonstrated the expression of this group in the differentiated portions of the hair cortex.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-202X
1523-1747
DOI:10.1046/j.0022-202x.2001.01653.x