A 3-year follow-up study of radiotherapy using computed tomography–based image-guided brachytherapy for cervical cancer

• Published in: Journal of radiation research Vol. 60; no. 2; pp. 264 - 269
• Main Authors: Kawashima, Atsushi, Isohashi, Fumiaki, Mabuchi, Seiji, Sawada, Kenjiro, Ueda, Yutaka, Kobayashi, Eiji, Matsumoto, Yuri, Otani, Keisuke, Tamari, Keisuke, Seo, Yuji, Suzuki, Osamu, Sumida, Iori, Tomimatsu, Takuji, Kimura, Tadashi, Ogawa, Kazuhiko
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2019
• Subjects: Adenocarcinoma; Brachytherapy; Cancer research; Cancer treatment; Carboplatin; Carcinoma; Care and treatment; CAT scans; Cervical cancer; Chemotherapy; Diagnosis; Diagnostic imaging; Medical research; Methods; Patient outcomes; Radiotherapy; Regular Paper; Squamous cell carcinoma; Tomography; Tumors; Japan; computed tomography; image-guided brachytherapy; three-dimensional treatment planning; cervical cancer
• ISSN: 0449-3060; 1349-9157
• DOI: 10.1093/jrr/rry104

Abstract Outcomes for patients with Stage IB1–IVA cervical cancer treated with computed tomography (CT)-based image-guided brachytherapy (IGBT) were examined in this study. A total of 84 patients were analyzed between March 2012 and June 2015. Whole-pelvic radiotherapy with a central shield was performed for each patient, and the total pelvic sidewall dose was 50 Gy. IGBT was delivered in 2–4 fractions. The initial prescription dose (6.8 Gy) was delivered at Point A, and the dose distribution was modified manually by graphical optimization. The total dose was calculated as the biologically equivalent dose in 2 Gy fractions (EQD2). Concurrent chemotherapy was administered to 64 patients (76%). The median follow-up period was 36 months (range 2–62 months). The 3-year overall survival, local control, and progression-free survival rates were 94%, 89% and 81%, respectively. The mean EQD2 for HR-CTV D90 was 73.4 Gy, and the EQD2 for HR-CTV D90 was not significantly associated with the local control rate. In multivariate analysis, adenocarcinoma (P = 0.03) and tumor size ≥45 mm (P = 0.06) were risk factors for local control. The patients were divided into four groups based on histology (squamous cell carcinoma vs adenocarcinoma) and tumor size (<45 vs ≥45 mm). Those with large adenocarcinomas had significantly worse outcomes. In conclusion, CT-based IGBT achieved favorable local control, but different treatment strategies may be necessary for large adenocarcinomas.