The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 12
• Main Authors: Lu, XinGang, Xue, JingWei, Shen, QiXing, Xu, XiaoLi, Wang, YiRu, Ye, Jie, Gou, HaiXing, Zhao, Jie
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Anti-inflammatory agents; Arthritis; Biomedical research; Carrageenan; Cartilage; Citrus fruits; Cyclooxygenase-2; Cytokines; Cytotoxicity; Diabetes; Edema; Experiments; Geriatrics; Health aspects; Inflammation; Interleukin 1; Interleukin 6; Laboratories; Lipopolysaccharides; MAP kinase; Meliaceae; mRNA; Nitric-oxide synthase; Phytochemicals; Polymerase chain reaction; Prevention; Rats; Rheumatoid arthritis; Rodents; Signaling; Staining; Toluidine; Toluidine blue; Toona ciliata; Traditional Chinese medicine; Tumor necrosis factor; Tumor necrosis factor-TNF; China

Toonaciliatin K is a natural limonoid purified from the Toona ciliata Roem. var. ciliata (Meliaceae). This study is to reveal the inflammatory suppression effect of toonaciliatin K and further the intrinsic mechanism. Firstly, anti-inflammatory effect of toonaciliatin K was evaluated in lipopolysacc...