Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, le...

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Published inBioMed research international Vol. 2019; no. 2019; pp. 1 - 16
Main Authors Beninati, Simone, Tabolacci, Claudio, Jadeja, Ravirajsinh N., Valle, Giorgia, Norelli, Sandro, D’Arcangelo, Daniela, Facchiano, Antonio, Pieretti, Stefano, Bartoli, Manuela, Facchiano, Francesco, Forni, Cinzia, Nisini, Roberto
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
John Wiley & Sons, Inc
Subjects
Age related diseases
Aging
Aging (natural)
Antioxidants
Cancer
Cardiovascular diseases
Carotenoids
Cellular manufacture
Deoxyribonucleic acid
Dermatitis
Dermatology
Diabetes
Diabetes mellitus
DNA
DNA damage
Flavonoids
Fruits
Functionals
Inflammation
Lipids
Melanoma
Metabolic disorders
Metabolic syndrome
Metabolism
Metabolites
Nervous system diseases
Neurodegenerative diseases
Neurological diseases
Oxidative stress
Phytochemicals
Polyphenols
Proteins
Reactive oxygen species
Review
Side effects
Skin
Vitamin C
Online AccessGet full text

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Abstract Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.
AbstractList Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.
Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.
Audience Academic
Author Valle, Giorgia
Facchiano, Antonio
D’Arcangelo, Daniela
Bartoli, Manuela
Nisini, Roberto
Pieretti, Stefano
Facchiano, Francesco
Beninati, Simone
Tabolacci, Claudio
Jadeja, Ravirajsinh N.
Norelli, Sandro
Forni, Cinzia
AuthorAffiliation 2 Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
1 Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
5 Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy
6 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy
3 Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, USA
7 Department of Medicine, University Campus Bio-Medico, Rome, Italy
4 National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy
8 Department of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, USA
AuthorAffiliation_xml – name: 1 Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
– name: 6 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy
– name: 7 Department of Medicine, University Campus Bio-Medico, Rome, Italy
– name: 3 Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, USA
– name: 4 National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy
– name: 2 Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
– name: 5 Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy
– name: 8 Department of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, USA
Author_xml – sequence: 1
  fullname: Beninati, Simone
– sequence: 2
  fullname: Tabolacci, Claudio
– sequence: 3
  fullname: Jadeja, Ravirajsinh N.
– sequence: 4
  fullname: Valle, Giorgia
– sequence: 5
  fullname: Norelli, Sandro
– sequence: 6
  fullname: D’Arcangelo, Daniela
– sequence: 7
  fullname: Facchiano, Antonio
– sequence: 8
  fullname: Pieretti, Stefano
– sequence: 9
  fullname: Bartoli, Manuela
– sequence: 10
  fullname: Facchiano, Francesco
– sequence: 11
  fullname: Forni, Cinzia
– sequence: 12
  fullname: Nisini, Roberto
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31080832$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2019 Cinzia Forni et al.
COPYRIGHT 2019 John Wiley & Sons, Inc.
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Snippet Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen...
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SubjectTerms Age related diseases
Aging
Aging (natural)
Antioxidants
Cancer
Cardiovascular diseases
Carotenoids
Cellular manufacture
Deoxyribonucleic acid
Dermatitis
Dermatology
Diabetes
Diabetes mellitus
DNA
DNA damage
Flavonoids
Fruits
Functionals
Inflammation
Lipids
Melanoma
Metabolic disorders
Metabolic syndrome
Metabolism
Metabolites
Nervous system diseases
Neurodegenerative diseases
Neurological diseases
Oxidative stress
Phytochemicals
Polyphenols
Proteins
Reactive oxygen species
Review
Side effects
Skin
Vitamin C
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Title Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
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https://dx.doi.org/10.1155/2019/8748253
https://www.ncbi.nlm.nih.gov/pubmed/31080832
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Volume 2019
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