Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

• Published in: BioMed research international Vol. 2019; no. 2019; pp. 1 - 16
• Main Authors: Beninati, Simone, Tabolacci, Claudio, Jadeja, Ravirajsinh N., Valle, Giorgia, Norelli, Sandro, D’Arcangelo, Daniela, Facchiano, Antonio, Pieretti, Stefano, Bartoli, Manuela, Facchiano, Francesco, Forni, Cinzia, Nisini, Roberto
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; John Wiley & Sons, Inc
• Subjects: Age related diseases; Aging; Aging (natural); Antioxidants; Cancer; Cardiovascular diseases; Carotenoids; Cellular manufacture; Deoxyribonucleic acid; Dermatitis; Dermatology; Diabetes; Diabetes mellitus; DNA; DNA damage; Flavonoids; Fruits; Functionals; Inflammation; Lipids; Melanoma; Metabolic disorders; Metabolic syndrome; Metabolism; Metabolites; Nervous system diseases; Neurodegenerative diseases; Neurological diseases; Oxidative stress; Phytochemicals; Polyphenols; Proteins; Reactive oxygen species; Review; Side effects; Skin; Vitamin C
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2019/8748253

Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.