A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity

• Published in: Trends in neurosciences (Regular ed.) Vol. 21; no. 7; pp. 273 - 278
• Main Authors: Paulsen, Ole, Moser, Edvard
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.1998; Elsevier Science; Elsevier Sequoia S.A
• Subjects: back propogation; Biological and medical sciences; Brain; Electroencephalography; Fundamental and applied biological sciences. Psychology; gamma-Aminobutyric Acid - biosynthesis; General aspects. Models. Methods; hippocampus; Hippocampus - physiology; Hippocampus - ultrastructure; Humans; Information storage; inhibition; interneurones; learning; LTP; Memory - physiology; Mental Processes - classification; Mental Processes - physiology; Models, Neurological; Neurology; Neuronal Plasticity - physiology; Neurons; Neurons - classification; Neurons - ultrastructure; phasing; Receptors, GABA - physiology; Synaptic Transmission - physiology; theta; Vertebrates: nervous system and sense organs; interneurones; hippocampus; phasing; inhibition; LTP; learning; back propogation; theta; Synaptic transmission; Memory; Central nervous system; Synaptic plasticity; Gabaergic transmission; Review; Hippocampus; Gabaergic neurone; Brain (vertebrata); Interneuron
• ISSN: 0166-2236; 1878-108X
• DOI: 10.1016/S0166-2236(97)01205-8

The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.