Exploring paraptosis as a therapeutic approach in cancer treatment

• Published in: Journal of biomedical science Vol. 31; no. 1; pp. 101 - 23
• Main Authors: Chang, Ling-Chu, Chiang, Shih-Kai, Chen, Shuen-Ei, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.11.2024; BioMed Central; BMC
• Subjects: Apoptosis; Auranofin; Autophagy; Cancer; Cancer cells; Cancer therapies; Caspase; Cell cycle; Cell Death; Cyclin-dependent kinases; Endoplasmic reticulum; Endoplasmic reticulum stress; Health aspects; Homeostasis; Humans; Ion homeostasis; Kinases; Mitochondria; Morphology; Mortality; Natural products; Necrosis; Neoplasms - therapy; Oxidative stress; Paraptosis; Prevention; Proteasome inhibition; Proteins; Review; Signal Transduction; Mitochondria; Reactive oxygen species; Proteasome inhibition; Cancer cells; Paraptosis; Ion homeostasis; Endoplasmic reticulum stress
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/s12929-024-01089-4

A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment.