Clinical characteristics and potential association to Parkinson’s disease and dementia with Lewy bodies in patients with major depressive disorder who received maintenance electroconvulsive therapy: a retrospective chart review study

• Published in: BMC psychiatry Vol. 23; no. 1; pp. 243 - 8
• Main Authors: Kudo, Shun, Uchida, Takahito, Nishida, Hana, Takamiya, Akihiro, Kikuchi, Toshiaki, Yamagata, Bun, Mimura, Masaru, Hirano, Jinichi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.04.2023; BioMed Central; BMC
• Subjects: Alzheimer Disease; Analysis; Antidepressants; Care and treatment; Cognition disorders; Complications and side effects; Computed tomography; DaT-SPECT; Dementia disorders; Dementia with Lewy bodies; Depressive Disorder, Major; Dopamine transporter; Electroconvulsive therapy; Electroconvulsive Therapy - methods; Humans; Lewy bodies; Lewy Body Disease; Maintenance ECT; Major depressive disorder; Mental depression; MIBG scintigraphy; Movement disorders; Nervous system; Neurodegenerative diseases; Neuroimaging; Parkinson Disease; Parkinson's disease; Patient outcomes; Prevention; Psychiatry; Remission; Retrospective Studies; Risk factors; Scintigraphy; Single photon emission computed tomography; SPECT imaging; Japan; Maintenance ECT; MIBG scintigraphy; Major depressive disorder; Parkinson’s disease; DaT-SPECT; Dementia with Lewy bodies
• ISSN: 1471-244X; 1471-244X
• DOI: 10.1186/s12888-023-04743-7

Maintaining remission after electroconvulsive therapy (ECT) is clinically relevant in patients with depression, and maintenance ECT has been introduced in patients who fail to maintain remission after ECT. However, the clinical characteristics and biological background of patients who receive maintenance ECT are poorly understood. Thus, this study aimed to examine the clinical background of patients who underwent maintenance ECT. Patients with major depressive disorder who underwent ECT followed by maintenance ECT (mECT group) and those who did not (acute ECT [aECT] group) were included. Clinical characteristics, including the results of neuroimaging examinations for Parkinson's disease (PD) and dementia with Levy body (DLB) such as myocardial 123I-metaiodobenzylguanidine (MIBG) scintigraphy and dopamine transporter imaging single-photon emission computerized tomography (DaT-SPECT), were compared between the groups. In total, 13 and 146 patients were included in the mECT and aECT groups, respectively. Compared to the aECT group, the mECT group showed a significantly higher prevalence of melancholic features (92.3% vs. 27.4%, p < 0.001) and catatonic features (46.2% vs. 9.6%, p = 0.002). Overall, 8 of the 13 patients in the mECT group and 22 of the 146 patients in the aECT group underwent neuroimaging examinations for PD/DLB. The rate of patients examined is significantly higher in the mECT group than in the aECT group (61.5% vs. 11.2%, p < 0.001). Among the groups examined, 7/8 patients in the mECT group and 16/22 patients in the aECT group showed relevant neuroimaging findings for PD/DLB; the positive rate was not significantly different between the two groups (87.5% vs. 72.7%, p = 0.638). Patients who receive acute and maintenance ECT may have underlying neurodegenerative diseases, including PD/DLB. Investigating the neurobiology of patients who receive maintenance ECT is important for developing appropriate treatments for depression.