Macrophages and Cell-Cell Spread of HIV-1

Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of vir...

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Bibliographic Details
Published inViruses Vol. 2; no. 8; pp. 1603 - 1620
Main Authors Waki, Kayoko, Freed, Eric O
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 01.08.2010
Molecular Diversity Preservation International (MDPI)
Subjects
HIV-1
Human immunodeficiency virus 1
macrophage
Review
synapse
transmission
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Summary:Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v2081603