Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

• Published in: Nature Vol. 447; no. 7143; pp. 487 - 492
• Main Authors: McDonald, N. Q, Fox, G. C, Shafiq, M, Briggs, D. C, Knowles, P. P, Collister, M, Didmon, M. J, Makrantoni, V, Dickinson, R. J, Hanrahan, S, Totty, N, Stark, M. J. R, Keyse, S. M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 24.05.2007; Nature Publishing Group
• Subjects: Amino Acid Sequence; Binding Sites; Biochemistry; Biological and medical sciences; Catalysis; Cell physiology; Cellular biology; Cysteine - metabolism; Disulfides - metabolism; Dual-Specificity Phosphatases; Fundamental and applied biological sciences. Psychology; Fungi - enzymology; Histidine - metabolism; Humans; Kinases; Models, Molecular; Molecular and cellular biology; Molecular Sequence Data; Molecular structure; Oxidation; Oxidation-Reduction - drug effects; Oxidative Stress; Phosphoprotein Phosphatases - chemistry; Phosphoprotein Phosphatases - classification; Phosphoprotein Phosphatases - metabolism; Phosphotyrosine - metabolism; Protein Tyrosine Phosphatases - chemistry; Protein Tyrosine Phosphatases - classification; Protein Tyrosine Phosphatases - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - classification; Saccharomyces cerevisiae Proteins - metabolism; Signal transduction; Substrate Specificity; Substrates; Taxa; Yeasts; Substrate; Oxidative stress; Enzyme; Phosphoprotein phosphatase; Phosphoric monoester hydrolases; Mitogen-activated protein kinase; Hydrolases; Esterases; Dephosphorylation; Recognition; Cell signaling; Protein-tyrosine-phosphatase

Reactive oxygen species trigger cellular responses by activation of stress-responsive mitogen-activated protein kinase (MAPK) signalling pathways. Reversal of MAPK activation requires the transcriptional induction of specialized cysteine-based phosphatases that mediate MAPK dephosphorylation. Parado...