Distal Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination in a Patient with Solitary Plasmacytoma: A Case Report and Literature Review

We herein report a rare case of distal chronic inflammatory demyelinating polyneuropathy (CIDP) following coronavirus disease 2019 (COVID-19) vaccination. A 39-year-old woman with a solitary plasmacytoma developed general weakness 7 days after receiving the second dose of the Pfizer-BioNTech COVID-1...

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Published inInternal Medicine Vol. 62; no. 16; pp. 2419 - 2425
Main Authors Kubota, Takafumi, Shijo, Tomomi, Ikeda, Kensho, Mitobe, Yoshihiko, Umezawa, Shu, Misu, Tatsuro, Hasegawa, Takafumi, Aoki, Masashi
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Internal Medicine 15.08.2023
Japan Science and Technology Agency
Subjects
anti-ganglioside antibody
Case Report
CIDP
Coronaviruses
COVID-19
COVID-19 vaccines
Demyelination
Gangliosides
Immunoglobulin G
Inflammation
Internal medicine
Intravenous administration
Literature reviews
Methylprednisolone
myeloma
Plasmacytoma
Polyneuropathy
Prednisolone
Serological tests
vaccination
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Summary:We herein report a rare case of distal chronic inflammatory demyelinating polyneuropathy (CIDP) following coronavirus disease 2019 (COVID-19) vaccination. A 39-year-old woman with a solitary plasmacytoma developed general weakness 7 days after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine, which had progressed for 3 months. A neurological examination revealed limb weakness with areflexia. Serological tests identified the presence of IgG antibodies against anti-GM1 and anti-GM2 gangliosides. Comprehensive evaluations met the criteria of distal CIDP. Intravenous immunoglobulin, intravenous methylprednisolone, oral prednisolone, and plasma exchange were administered, and she gradually improved. Physicians should be aware of CIDP as a rare complication of COVID-19 vaccination.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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Correspondence to Dr.　Takafumi Hasegawa, thasegawa@med.tohoku.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1365-22