Binding and entering: COVID finds a new home

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In t...

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Published inPLoS pathogens Vol. 17; no. 8; p. e1009857
Main Authors Vu, Michelle N, Menachery, Vineet D
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.08.2021
Public Library of Science (PLoS)
Subjects
Angiotensin-Converting Enzyme 2 - metabolism
Biology and life sciences
Causes of
Coronaviruses
COVID-19 - metabolism
COVID-19 - virology
Epidemics
Genetic aspects
Health aspects
Humans
Medicine and health sciences
Pearls
Protein binding
SARS-CoV-2 - pathogenicity
SARS-CoV-2 - physiology
Spike Glycoprotein, Coronavirus - metabolism
United States
Viral proteins
Virulence (Microbiology)
Virus Internalization
United States
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Summary:Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.
Bibliography:ObjectType-Article-1
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1009857