Gut microbial metabolites SCFAs and chronic kidney disease

• Published in: Journal of translational medicine Vol. 22; no. 1; pp. 172 - 18
• Main Authors: He, Meng, Wei, Wenqian, Zhang, Yichen, Xiang, Zhouxia, Peng, Dan, Kasimumali, Ayijiaken, Rong, Shu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.02.2024; BioMed Central; BMC
• Subjects: Analysis; Autophagy; Bacteria; Biomarkers; Cardiovascular disease; Care and treatment; Chronic kidney failure; CKD; Colon; Composition; Diabetes; Diagnosis; Digestive system; Energy balance; Fatty acids; Fatty Acids, Volatile - metabolism; Fatty Acids, Volatile - therapeutic use; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Gut microbial metabolites; Health aspects; Homeostasis; Humans; Hypertension; Immune response; Inflammation; Inflammatory responses; Intestinal microflora; Intestine; Kidney diseases; Kinases; Metabolism; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Mortality; Oxidative stress; Prognosis; Renal Insufficiency, Chronic - drug therapy; Review; Risk factors; SCFAs; Signal Transduction; China; Inflammatory responses; Oxidative stress; SCFAs; CKD; Gut microbial metabolites
• ISSN: 1479-5876; 1479-5876
• DOI: 10.1186/s12967-024-04974-6

The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain of intestinal microecology. The intestinal microbiota orchestrates a dynamic equilibrium in the organism, metabolizing dietary-derived compounds, a process which profoundly impacts human health. Among these compounds, short-chain fatty acids (SCFAs), which result from microbial metabolic processes, play a versatile role in influencing host energy homeostasis, immune function, and intermicrobial signaling, etc. SCFAs emerge as pivotal risk factors influencing CKD's development and prognosis. This paper review elucidates the impact of gut microbial metabolites, specifically SCFAs, on CKD, highlighting their role in modulating host inflammatory responses, oxidative stress, cellular autophagy, the immune milieu, and signaling cascades. An in-depth comprehension of the interplay between SCFAs and kidney disease pathogenesis may pave the way for their utilization as biomarkers for CKD progression and prognosis or as novel adjunctive therapeutic strategies.